After a year of the regimen, scientists examined the DNA of each volunteer and determined from the results that on the average, each of the subjects took 2.5 years off their biological age. The study was conducted in the United States and every volunteer self-administered the drugs multiple times during the week for an entire year. The volunteers received a drug cocktail which included a non-prescription hormone supplement (DHEA), a medication used in treating diabetes (Metformin), and growth hormone. The study was made up of nine volunteers, who were all white males and ranged between 51 and 65 years of age. The changes in the biological age were calculated by the DNA changes which accrue as people get older. Medical researchers discovered that by taking a specific combination of drugs, the subjects were able to reverse their biological age. Study Proves Reality of Reversing Your Biological Age The predictor of human morbidity and mortality are known as the Grim Age showed a decrease of 2 years in epigenetic compared to chronological age and continued even 6 months the study ended. The TRIIM study researchers focused on being able to restore the thymus and saw protective changes in the subject’s immunology, lowered risk for many age-related diseases, and an average decrease of epigenetic age of approximately 2.5 years. The TRIIM study relied on four estimators of aging that were used to show that epigenetic aging was reversible in humans. Today, epigenetic clocks are far superior to the chronological age method for determining biological age. The TRIIM study clearly supports this methodology, having confirmed the reversion of epigenetic age with important statistical impact despite only having a one‐year pilot study having only 9 volunteers.Īn epigenetic clock is a test method of calculating a person’s age based on levels of DNA methylation, a biomarker of aging. This substantiates using epigenetic clocks to determine the success of accepted aging interference on a realistic timescale. What is Epigenetic AgeĮven though epigenetic age is not the only gauge that encompasses all characteristics of aging, today it provides the most precise determination of biological age as well as the risk of age‐related disease. However, there had not been any evidence showing that epigenetic age can be reversed, until now. The results obtained in the animal studies showed a reversal in aging using physiological methods in mature mammals.
#Chronological age and biological age how to
Biological age is determined by developmental factors which include:Ī person with a significantly lower biological age than his or her chronological age will live longer than a person whose biological and chronological age is similar.ĭuring the last decade, both medical and clinical methods of studying how to improve aging have primarily been conducted using animal subjects.
Generally, this is the main way people express their actual age.īiological age, which is also known as functional or physiological age, refers to aging as a result of the breakdown in the body’s cells and tissues. Your chronological age is the actual number of years that have passed since you were born. Chronological Age and Biological Age Differences Generally, the TCR begins to collapse after age 60 and is associated with increased incidences of atherosclerosis, autoimmune conditions, cancer, infectious disease, and overall mortality. The objective of the TRIIM study was to examine whether recombinant human growth hormone (rhGH) could be used in the prevention and/or reversal of immune-senescence (the slow and progressive breakdown of the immune system caused by aging) in middle-aged healthy males, representative of the age range subsequent to the breakdown of the T-cell Receptor (TCR). Scientists have also learned that a person’s biological age is the superior predictor for longevity when compared with chronological age.
In the last few years, scientists have also created tests that can accurately calculate your biological age. While you cannot reverse your chronological age, the results of the TRIIM study showed that it is possible to rewind your biological clock and scientists were shocked at the results.
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